The mechanisms of ultra-low dose opioid agonist-antagonist
نویسندگان
چکیده
منابع مشابه
Opioids and Glia: Investigating the Mechanisms through Which Ultra-low Dose Opioid Antagonists Modulate Opioid Tolerance and Hyperalgesia
........................................................................................................................................... ii Co-Authorship ................................................................................................................................ iv Acknowledgements ..............................................................................................
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Ultra-low-dose opioid antagonists, when combined with opiates, increase the analgesic efficacy and duration of analgesia of the opiate. This enhanced and prolonged analgesia was recently demonstrated in a 350-patient Phase II clinical trial of Oxytrex, a novel drug candidate that combines oxycodone with an ultra-low dose of the opioid antagonist naltrexone. Extensive preclinical data also show ...
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Opioid agonists and antagonists can regulate the density of mu-opioid receptors in whole animal and in cell culture. High intrinsic efficacy agonists (e.g., etorphine), but not lower intrinsic efficacy agonists (e.g., morphine), produce mu-opioid receptor down-regulation and can alter the abundance of mu-opioid receptor mRNA. Conversely, opioid antagonists substantially increase the density of ...
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Patients taking high-dose opioids chronically for tumor-related or neuropathic pain may develop pain that is refractory to opioids. One option for control of such pain is the use of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. We describe a case of opioid-refractory pain that responded to a low-dose IV infusion of ketamine in the inpatient setting. The patient was then successf...
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ژورنال
عنوان ژورنال: Journal of the Formosan Medical Association
سال: 2011
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2011.08.013